Abstract This paper addresses a challenging problem of regularizing arbitrary superpixels into an optimal grid structure, which may significantly extend current low-level vision algorithms by allowing them to use superpixels (SPs) conveniently as using pixels. For this purpose, we aim at constructing maximum cohesive SP-grid, which is composed of real nodes, i.e. SPs, and dummy nodes that are meaningless in the image with only position-taking function in the grid. For a given formation of image SPs and proper number of dummy nodes, we first dynamically align them into a grid based on the centroid localities of SPs. We then define the SP-grid coherence as the sum of edge weights, with SP locality and appearance encoded, along all direct paths connecting any two nearest neighboring real nodes in the grid. We finally maximize the SP-grid coherence via cascade dynamic programming. Our approach can take the regional objectness as an optional constraint to produce more semantically reliable SP-grids. Experiments on object localization show that our approach outperforms state-of-the-art methods in terms of both detection accuracy and speed. We also find that with the same searching strategy and features object localization at SP-level is about 100-500 times faste than pixel-level, with usually better detection accuracy.