Abstract In this paper, we propose a novel graph neural network with generated parameters (GPGNNs). The parameters in the propagation module, i.e. the transition matrices used in message passing procedure, are produced by a generator taking natural language sentences as inputs. We verify GP-GNNs in relation extraction from text, both on bag- and instancesettings. Experimental results on a humanannotated dataset and two distantly supervised datasets show that multi-hop reasoning mechanism yields significant improvements. We also perform a qualitative analysis to demonstrate that our model could discover more accurate relations by multi-hop relational reasoning. Codes and data are released at https: //github.com/thunlp/gp-gnn.