Abstract

Recently, groupwise registration has been investigated for simultaneous alignment of all images without selecting any individual image as the template, thus avoiding the potential bias in image registration. However, none of current groupwise registration method fully utilizes the image distribution to guide the registration. Thus, the registration performance usually suffers from large inter-subject variations across individual images. To solve this issue, we propose a novel groupwise registration algorithm for large population dataset, guided by the image distribution on the manifold. Specififically, we fifirst use a graph to model the distribution of all image data sitting on the image manifold, with each node representing an image and each edge representing the geodesic pathway between two nodes (or images). Then, the procedure of warping all images to their population center turns to the dynamic shrinking of the graph nodes along their graph edges until all graph nodes become close to each other. Thus, the topology of image distribution on the image manifold is always preserved during the groupwise registration. More importantly, by modeling the distribution of all images via a graph, we can potentially reduce registration error since every time each image is warped only according to its nearby images with similar structures in the graph. We have evaluated our proposed groupwise registration method on both synthetic and real datasets, with comparison to the two state-of-the-art groupwise registration methods. All experimental results show that our proposed method achieves the best performance in terms of registration accuracy and robustness.