遗传突变分类竞赛【Kaggle竞赛】
Overview:
A lot has been said during the past several years about how precision medicine and, more concretely, how genetic testing is going to disrupt the way diseases like cancer are treated.
But this is only partially happening due to the huge amount of manual work still required. Memorial Sloan Kettering Cancer Center (MSKCC) launched this competition, accepted by the NIPS 2017 Competition Track, because we need your help to take personalized medicine to its full potential.
Once sequenced, a cancer tumor can have thousands of genetic mutations. But the challenge is distinguishing the mutations that contribute to tumor growth (drivers) from the neutral mutations (passengers).
Currently this interpretation of genetic mutations is being done manually. This is a very time-consuming task where a clinical pathologist has to manually review and classify every single genetic mutation based on evidence from text-based clinical literature.
For this competition MSKCC is making available an expert-annotated knowledge base where world-class researchers and oncologists have manually annotated thousands of mutations.
We need your help to develop a Machine Learning algorithm that, using this knowledge base as a baseline, automatically classifies genetic variations.
Kaggle is excited to partner with research groups to push forward the frontier of machine learning. Research competitions make use of Kaggle's platform and experience, but are largely organized by the research group's data science team. Any questions or concerns regarding the competition data, quality, or topic will be addressed by them.
Data Description
In this competition you will develop algorithms to classify genetic mutations based on clinical evidence (text).
There are nine different classes a genetic mutation can be classified on.
This is not a trivial task since interpreting clinical evidence is very challenging even for human specialists. Therefore, modeling the clinical evidence (text) will be critical for the success of your approach.
Both, training and test, data sets are provided via two different files. One (training/test_variants) provides the information about the genetic mutations, whereas the other (training/test_text) provides the clinical evidence (text) that our human experts used to classify the genetic mutations. Both are linked via the ID field.
Therefore the genetic mutation (row) with ID=15 in the file training_variants, was classified using the clinical evidence (text) from the row with ID=15 in the file training_text
Finally, to make it more exciting!! Some of the test data is machine-generated to prevent hand labeling. You will submit all the results of your classification algorithm, and we will ignore the machine-generated samples.
training_variants - a comma separated file containing the description of the genetic mutations used for training. Fields are ID (the id of the row used to link the mutation to the clinical evidence), Gene (the gene where this genetic mutation is located), Variation (the aminoacid change for this mutations), Class (1-9 the class this genetic mutation has been classified on)
training_text - a double pipe (||) delimited file that contains the clinical evidence (text) used to classify genetic mutations. Fields are ID (the id of the row used to link the clinical evidence to the genetic mutation), Text (the clinical evidence used to classify the genetic mutation)
test_variants - a comma separated file containing the description of the genetic mutations used for training. Fields are ID (the id of the row used to link the mutation to the clinical evidence), Gene (the gene where this genetic mutation is located), Variation (the aminoacid change for this mutations)
test_text - a double pipe (||) delimited file that contains the clinical evidence (text) used to classify genetic mutations. Fields are ID (the id of the row used to link the clinical evidence to the genetic mutation), Text (the clinical evidence used to classify the genetic mutation)
submissionSample - a sample submission file in the correct format
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