Abstract Domain adaptation is an essential task in dialog system building because there are so many new dialog tasks created for different needs every day. Collecting and annotating training data for these new tasks is costly since it involves real user interactions. We propose a domain adaptive dialog generation method based on meta-learning (DAML). DAML is an end-to-end trainable dialog system model that learns from multiple rich-resource tasks and then adapts to new domains with minimal training samples. We train a dialog system model using multiple rich-resource singledomain dialog data by applying the modelagnostic meta-learning algorithm to dialog domain. The model is capable of learning a competitive dialog system on a new domain with only a few training examples in an effi- cient manner. The two-step gradient updates in DAML enable the model to learn general features across multiple tasks. We evaluate our method on a simulated dialog dataset and achieve state-of-the-art performance, which is generalizable to new tasks