Abstract In Spatial Crowdsourcing (SC) systems, mobile users are enabled to perform spatio-temporal tasks by physically traveling to specified locations with the SC platforms. SC platforms manage the systems and recruit mobile users to contribute to the SC systems, whose commercial success depends on the profit attained from the task requesters. In order to maximize its profit, an SC platform needs an online management mechanism to assign the tasks to suitable workers. How to assign the tasks to workers more cost-effectively with the spatio-temporal constraints is one of the most difficult problems in SC. To deal with this challenge, we propose a novel Profit-driven Task Assignment (PTA) problem, which aims to maximize the profit of the platform. Specifically, we first establish a task reward pricing model with tasks’ temporal constraints (i.e., expected completion time and deadline). Then we adopt an optimal algorithm based on tree decomposition to achieve the optimal task assignment and propose greedy algorithms to improve the computational efficiency. Finally, we conduct extensive experiments using real and synthetic datasets, verifying the practicability of our proposed methods