Abstract The key challenge of generative Visual Dialogue (VD) systems is to respond to human queries with informative answers in natural and contiguous conversation flflow. Traditional Maximum Likelihood Estimation-based methods only learn from positive responses but ignore the negative responses, and consequently tend to yield safe or generic responses. To address this issue, we propose a novel training scheme in conjunction with weighted likelihood estimation method. Furthermore, an adaptive multi-modal reasoning module is designed, to accommodate various dialogue scenarios automatically and select relevant information accordingly. The experimental results on the VisDial benchmark demonstrate the superiority of our proposed algorithm over other state-of-the-art approaches, with an improvement of 5.81% on recall@10