Abstract End-to-end neural models for intelligent dialogue systems suffer from the problem of generating uninformative responses. Various methods were proposed to generate more informative responses by leveraging external knowledge. However, few previous work has focused on selecting appropriate knowledge in the learning process. The inappropriate selection of knowledge could prohibit the model from learning to make full use of the knowledge. Motivated by this, we propose an end-to-end neural model which employs a novel knowledge selection mechanism where both prior and posterior distributions over knowledge are used to facilitate knowledge selection. Specifically, a posterior distribution over knowledge is inferred from both utterances and responses, and it ensures the appropriate selection of knowledge during the training process. Meanwhile, a prior distribution, which is inferred from utterances only, is used to approximate the posterior distribution so that appropriate knowledge can be selected even without responses during the inference process. Compared with the previous work, our model can better incorporate appropriate knowledge in response generation. Experiments on both automatic and human evaluation verify the superiority of our model over previous baselines