Abstract Relative attribute models can compare images in terms of all detected properties or attributes, exhaustively predicting which image is fancier, more natural, and so on without any regard to ordering. However, when humans compare images, certain differences will naturally stick out and come to mind first. These most noticeable differences, or prominent differences, are likely to be described first. In addition, many differences, although present, may not be mentioned at all. In this work, we introduce and model prominent differences, a rich new functionality for comparing images. We collect instance-level annotations of most noticeable differences, and build a model trained on relative attribute features that predicts prominent differences for unseen pairs. We test our model on the challenging UT-Zap50K shoes and LFW10 faces datasets, and outperform an array of baseline methods. We then demonstrate how our prominence model improves two vision tasks, image search and description generation, enabling more natural communication between people and vision systems