Abstract We propose a simple and efficient method for exploiting synthetic images when training a Deep Network to predict a 3D pose from an image. The ability of using synthetic images for training a Deep Network is extremely valuable as it is easy to create a virtually infinite training set made of such images, while capturing and annotating real images can be very cumbersome. However, synthetic images do not resemble real images exactly, and using them for training can result in suboptimal performance. It was recently shown that for exemplar-based approaches, it is possible to learn a mapping from the exemplar representations of real images to the exemplar representations of synthetic images. In this paper, we show that this approach is more general, and that a network can also be applied after the mapping to infer a 3D pose: At run-time, given a real image of the target object, we first compute the features for the image, map them to the feature space of synthetic images, and finally use the resulting features as input to another network which predicts the 3D pose. Since this network can be trained very effectively by using synthetic images, it performs very well in practice, and inference is faster and more accurate than with an exemplar-based approach. We demonstrate our approach on the LINEMOD dataset for 3D object pose estimation from color images, and the NYU dataset for 3D hand pose estimation from depth maps. We show that it allows us to outperform the state-of-the-art on both datasets