Abstract. 3D human pose estimation from a single image is a challenging problem, especially for in-the-wild settings due to the lack of 3D annotated data. We propose two anatomically inspired loss functions and use them with a weaklysupervised learning framework to jointly learn from large-scale in-the-wild 2D and indoor/synthetic 3D data. We also present a simple temporal network that exploits temporal and structural cues present in predicted pose sequences to temporally harmonize the pose estimations. We carefully analyze the proposed contributions through loss surface visualizations and sensitivity analysis to facilitate deeper understanding of their working mechanism. Jointly, the two networks capture the anatomical constraints in static and kinetic states of the human body. Our complete pipeline improves the state-of-the-art by 11.8% and 12% on Human3.6M and MPI-INF-3DHP, respectively, and runs at 30 FPS on a commodity graphics card.