Abstract We aim to automatically generate human motion sequence from a single input person image, with some specific action label. To this end, we propose a cross-space human motion video generation network which features two paths: a forward path that first samples/generates a sequence of low dimensional motion vectors based on Gaussian Process (GP), which is paired with the input person image to form a moving human figure sequence; and a backward path based on the predicted human images to re-extract the corresponding latent motion representations. As lack of supervision, the reconstructed latent motion representations are expected to be as close as possible to the GP sampled ones, thus yielding a cyclic objective function for cross-space (i.e., motion and appearance) mutual constrained generation. We further propose an alternative sampling/generation algorithm with respect to constraints from both spaces. Extensive experimental results show that the proposed framework successfully generates novel human motion sequences with reasonable visual quality.